This study aims to analyze factors that affect economic growth in OIC member countries by using neo-classical model of economic growth and economic growth of Ibn Khaldun. The model consists of five variables, namely: labor, capital accumulation, agriculture, trade, and inflation. This study was using regression analysis of panel data with the object 20 OIC member countries (Afghanistan, Bangladesh, Mozambique, Togo, Uzbekistan, Indonesia, Nigeria, Pakistan, Tunisia, Jordan, Kazakhstan, Lebanon, Malaysia, Algeria, Turkey, Brunei, Kuwait, Oman, Arabia, and United Arab Emirates), from 2009 to 2013. The results showed that four of the five variables used to significantly affect the economic growth in OIC countries is variable labor, capital accumulation, agriculture, and trade, while inflation variable has no significant effect. From this study it can be concluded that not all the variables significantly influence economic growth in OIC countries.