The study aims to analyze the effect of E-Service Quality, namely the variables Reliability, Efficiency, Fulfillment, Privacy, Responsiveness, and Contact on JKN-KIS participants' satisfaction in the Social Security Organizing Agency (BPJS) Health. The study uses the method of Multiple Linear Regression with SPSS 21 software. Sample of 100 respondents. Respondents are JKN Mobile users. Research shows that the variables Reliability, Efficiency, Fulfillment, Privacy, Responsiveness, Contact simultaneously have a positive and significant effect on participant satisfaction. The study also showed that the efficiency, fulfillment, and responsiveness variables had a positive and significant effect on the satisfaction of JKN-KIS participants, and the Reliability, Privacy and Contact variables had a positive but not significant effect on participant satisfaction.