This study examines the complex dynamics of protective and risk factors that impact substance abuse among youth in high-risk neighborhoods. Using a qualitative methodology based on interviews with young people from these neighborhoods, it illuminates the nuanced subtleties that shape their experiences. Internally, the findings reveal significant vulnerabilities among young people, with a notable proportion experiencing a lack of spiritual knowledge and practice (43%)and succumbing to curiosity (38%). Stress pressure (14%) and initiation through smoking (5%) were also identified as factors contributing to their vulnerability. From an external perspective, the negative influence of peers (28) emerged as an important risk factor, followed by inadequate parental education (24%) and family involvement with drugs (19%). The negative effects of a negative neighborhood environment (17%), parental separation (9%) and type of occupation (4%) were also evident. However, amidst these risks, certain protective factors were also identified. Internal spiritual knowledge and practice (33%), awareness of the dangers of drugs (30%), positive peer influence (24%) and assertiveness (13%) demonstrated resilience to negative influences. Robust external protective factors included the ability to choose friends (42%), the positive influence of family (43%) and the ability to avoid drug hubs (14%), emphasizing the importance of social support structures and informed choices in risk reduction. This research emphasizes the complexity of protective and risk factors impacting young people in high-risk areas and provides valuable insights for policy makers, practitioners, and communities to develop targeted interventions aimed at promoting resilienceand safeguarding the wellbeing of vulnerable young people.